Advancement in Microsphere Preparation Using Natural Polymers and Recent Patents
Uzma Farooq, Rishabha Malviya and Pramod K. Sharma
Affiliation: Research Scholar, Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Plot No. 2, Sector 17-A, Yamuna Expressway, Greater Noida, Gautam Buddha Nagar, Uttar Pradesh, India.
In present study, Authors review all aspects of microsphere based novel drug delivery system; including need
of natural polymers, different approaches for preparation and recent advancements. Microspheres are a novel drug delivery
approach to control release of pharmacologically active ingredient as per patient needs. Natural polymers are cheap,
biodegradable and have been proved safe for pharmaceutical formulation. Microspheres of naturally derived polymers
have been prepared by several techniques like coacervation phase separation, emulsion polymerization, modified quasiemulsion
solvent diffusion, emulsion cross-linking, thermal denaturation, emulsification solvent evaporation, spray drying
and suspension polymerisation. It can be concluded from the whole patented study that due to the formation of polymeric
network system, enzyme, hormones or other active moiety can be easily entrapped within the matrix. Rate of hydration
and swelling of the natural polymer controls the release pattern of the drug from the matrix.
Keywords: Microsphere, natural polymers, novel drug delivery, patents.
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