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Medicinal Chemistry
ISSN (Print): 1573-4064
ISSN (Online): 1875-6638
VOLUME: 10
ISSUE: 3
DOI: 10.2174/1573406410666140218103022      Price:  $58









Antibacterial Activity of Thioetherhydroxyethylsulfonamide Derivatives

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Author(s): Walcimar T. Vellasco Junior, Guilherme P. Guedes, Victor Facchinetti, Thatyana R.A. Vasconcelos, Maria G.F. Vaz, Wilson Cunico, Marcus V.N. de Souza, Geraldo R. de Paula, Maria E.C.K. Fleming and Claudia R.B. Gomes
Pages 271-276 (6)
Abstract:
Thioetherhydroxyethylsulfonamide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923). Results have shown that compounds 8c and 9e display potent activity (MIC = 0.125 µg/mL) against E. coli when compared with the standard drug sulfamethoxazole (SMZ, MIC < 0.5 µg/mL) for this same strain. All the new compounds were fully identified and characterized by NMR (1H and 13C) and X-ray crystallography (for compound 8c). This class of compounds can be considered as a good starting point for the development of new lead molecules in the fight against multi-drug bacterial resistance.
Keywords:
Antibacterial, chemical biology, drugs, sulfonamides, thioetherhydroxyethylsulfonamides, X-Ray.
Affiliation:
Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos - Farmanguinhos. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, 21041-250, RJ, Brazil.