Synthesis and Antibacterial Activity of a Novel Class of Benzylidenrhodanine Based Furan Derivatives
Robabeh Baharfar, Sahar Peiman and Mojtaba Mohseni
Affiliation: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Keywords: Antibacterial activity, Benzylidenrhodanine, Dialkyl acetylenedicarboxylates, tert-butyl isocyanide.
A simple synthesis of novel benzylidenrhodanine based Furan derivatives was described from 5-arylidene 3-
carboxymethylrhodanine derivatives via multi-component reactions. The reactive 1:1 intermediate produced from the
reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 5-arylidene 3-
carboxymethylrhodanine derivatives to yield polyfunctionalized furan rings in fairly good yields. The products have been
analyzed for antibacterial activity against Gram positive and Gram negative bacteria. The results indicated that the
synthesized compounds are effective against bacterial growth retardation activity to some extent and their effectiveness is
higher for Staphylococcusaureus.
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