Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
Chung Man Chin, Diego Eidy Chiba, Marcella Gabrielle Mendes Machado, Ednir de Oliveira Vizioli and Jean Leandro dos Santos
Affiliation: Lapdesf- Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of Sao Paulo State – UNESP, Rodovia Araraquara-Jaú Km 1, CEP. 14801-902, Araraquara, SP, Brazil.
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended
to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery of
drug targets for CNS diseases opens a door for the selective treatment of these diseases. However, the physicochemical
properties of drugs, including their hydrophilic properties and their peripheral metabolism, as well as the blood–brain barrier,
can adversely affect the therapeutic potential of CNS-targeted drugs. Although peptides are often metabolized by enzymes,
they are of particular interest for the treatment of CNS diseases or as carriers to deliver drugs to the brain. In this
review, we discuss the use of peptides as potential prodrugs for the treatment of CNS diseases.
Keywords: Blood–brain barrier, Central nervous system, hydrophilic, physicochemical properties, peripheral metabolism, peptides.
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