Abstract
The present brief review looks at the evidence on the role of GLP-1 and its agonists in osteopenia and osteoporosis in type 2 diabetes (T2DM). There is accumulating data to suggest a favourable effect of GLP-1 on bone metabolism. However, most data is from experimental studies, while clinical confirmation is still inadequate. Moreover, little is known on the precise mechanisms underlying these effects. Therefore, we need randomised clinical trials in T2DM patients to learn more on the action of GLP-1 on bone metabolism and its potential clinical implications.
Keywords: Bone metabolism, fractures, GLP-1, incretins, type 2 diabetes mellitus.
Current Diabetes Reviews
Title:Role of Endogenous GLP-1 and its Agonists in Osteopenia and Osteoporosis: But We Little Know Until Tried
Volume: 10 Issue: 1
Author(s): Athanasia Papazafiropoulou, Nikolaos Papanas, Stavros Pappas and Efstratios Maltezos
Affiliation:
Keywords: Bone metabolism, fractures, GLP-1, incretins, type 2 diabetes mellitus.
Abstract: The present brief review looks at the evidence on the role of GLP-1 and its agonists in osteopenia and osteoporosis in type 2 diabetes (T2DM). There is accumulating data to suggest a favourable effect of GLP-1 on bone metabolism. However, most data is from experimental studies, while clinical confirmation is still inadequate. Moreover, little is known on the precise mechanisms underlying these effects. Therefore, we need randomised clinical trials in T2DM patients to learn more on the action of GLP-1 on bone metabolism and its potential clinical implications.
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Papazafiropoulou Athanasia, Papanas Nikolaos, Pappas Stavros and Maltezos Efstratios, Role of Endogenous GLP-1 and its Agonists in Osteopenia and Osteoporosis: But We Little Know Until Tried, Current Diabetes Reviews 2014; 10 (1) . https://dx.doi.org/10.2174/1573399810666140217114848
DOI https://dx.doi.org/10.2174/1573399810666140217114848 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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