Role of Endogenous GLP-1 and its Agonists in Osteopenia and Osteoporosis: But We Little Know Until Tried
Athanasia Papazafiropoulou, Nikolaos Papanas, Stavros Pappas and Efstratios Maltezos
Affiliation: Diabetes Centre, Third Department of Internal Medicine, General Hospital of Nikaia, Piraeus, Greece.
Keywords: Bone metabolism, fractures, GLP-1, incretins, type 2 diabetes mellitus.
The present brief review looks at the evidence on the role of GLP-1 and its agonists in osteopenia and osteoporosis
in type 2 diabetes (T2DM). There is accumulating data to suggest a favourable effect of GLP-1 on bone metabolism.
However, most data is from experimental studies, while clinical confirmation is still inadequate. Moreover, little is known
on the precise mechanisms underlying these effects. Therefore, we need randomised clinical trials in T2DM patients to
learn more on the action of GLP-1 on bone metabolism and its potential clinical implications.
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