Abstract
The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity which suggests that compound LG003 is a potential antitumor agent.
Keywords: 1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.
Letters in Drug Design & Discovery
Title:A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane
Volume: 11 Issue: 6
Author(s): Yinjiu Huang, Gang Liu, Xiaomei Hu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang and Xuehui Long
Affiliation:
Keywords: 1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.
Abstract: The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity which suggests that compound LG003 is a potential antitumor agent.
Export Options
About this article
Cite this article as:
Huang Yinjiu, Liu Gang, Hu Xiaomei, Liu Hao, Hu Jianguo, Feng Zhenzhong, Tang Bi, Qian Jun, Wang Qiyi and Long Xuehui, A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane, Letters in Drug Design & Discovery 2014; 11 (6) . https://dx.doi.org/10.2174/1570180811666140214204858
DOI https://dx.doi.org/10.2174/1570180811666140214204858 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
MicroRNA Gene Networks in Oncogenesis
Current Genomics Editorial
Recent Patents on Anti-Cancer Drug Discovery Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
Current Medicinal Chemistry Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors
Medicinal Chemistry The Two Faces of Protein Palmitoylation in Islet β-Cell Function: Potential Implications in the Pathophysiology of Islet Metabolic Dysregulation and Diabetes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery A Brief Review on Breast Carcinoma and Deliberation on Current Non Invasive Imaging Techniques for Detection
Current Medical Imaging Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Role of Nitric Oxide in the Modulation of Angiogenesis
Current Pharmaceutical Design Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release
Current Medicinal Chemistry High Specificity in Response of the Sodium-Dependent Multivitamin Transporter to Derivatives of Pantothenic Acid
Current Topics in Medicinal Chemistry Association of CA 15-3 and CEA with Liver Metastases in Patients with Breast Cancer
Current Cancer Therapy Reviews Alterations in Homocysteine Metabolism Among Alcohol Dependent Patients - Clinical, Pathobiochemical and Genetic Aspects
Current Drug Abuse Reviews Development and Characterization of Solid Dispersion System for Enhancing the Solubility and Dissolution Rate of Dietary Capsaicin
Current Drug Therapy The Role of Tumor Suppressor DLC-1: Far From Clear
Anti-Cancer Agents in Medicinal Chemistry Immunomodulatory Effect of Probiotic Bacteria
Recent Patents on Inflammation & Allergy Drug Discovery Potential Targets for Anti-Inflammatory and Anti-Allergic Activities of Marine Algae: An Overview
Inflammation & Allergy - Drug Targets (Discontinued) Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors
Clinical Cancer Drugs Recent Advances in Pharmacological Interventions of Chronic Prostatitis/ Chronic Pelvic Pain Syndrome
Current Pharmaceutical Design Role of Translocator Protein in Renal Ischemia Reperfusion, Renal Preservation and Acute Kidney Injury
Current Molecular Medicine Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?
Current Vascular Pharmacology