A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane
The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer
drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects
on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed
that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity
which suggests that compound LG003 is a potential antitumor agent.
Keywords: 1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.
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