A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane
Yinjiu Huang, Gang Liu, Xiaomei Hu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang and Xuehui Long
Affiliation: School of Chemistry and Materials Science, Ludong University, Yantai 264025, PR China.
The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer
drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects
on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed
that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity
which suggests that compound LG003 is a potential antitumor agent.
Keywords: 1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.
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