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Current Stem Cell Research & Therapy
ISSN (Print): 1574-888X
ISSN (Online): 2212-3946
VOLUME: 9
ISSUE: 3
DOI: 10.2174/1574888X09666140213203309









The Role of miRNAs in the Differentiation of Adipose-Derived Stem Cells

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Author(s): Jing Chen, Shuwen Deng, Shu Zhang, Zhaozhao Chen, Songtao Wu, Xiaoxiao Cai, Xingmei Yang, Bin Guo and Qiang Peng
Pages 268-279 (12)
Abstract:
MicroRNAs (miRNAs) are defined as a group of endogenous single-stranded noncoding RNAs that have the ability to downregulate gene expression. Recent research suggests that microRNAs (miRNAs) have a critical role in regulating the self-renewal and differentiation of mesenchymal stem cells (MSCs). MSCs, isolated from various adult tissue sources, are able to differentiate into multiple lineages, which are regulated by genetic and epigenetic mechanisms. Adipose- derived stem cells (ADSCs), originating from the vasculature of adipose tissue, share many properties of bone marrow mesenchymal stem cells (BMSCs). With advantages in both method and quantity of acquisition, ADSCs have become an alternative source of seeding cells. It has been shown that a complex system including various growth factors, transcription factors and signaling pathways could temporally control and regulate MSC differentiation into certain types of mature cells. This review briefly summarizes the biology of miRNAs and ADSCs. We then provide basic information regarding the molecular mechanisms of miRNA regulation in MSC differentiation and discuss several examples of that regulation in ADSC differentiation. Last, we provide perspectives on the progress in identification of the functions of miRNAs in ADSC differentiation.
Keywords:
Adipose-derived stem cells, differentiation, mesenchymal stem cells, miRNA, molecular mechanisms, signaling pathway.
Affiliation:
Institute of Stomatology, Chinese PLA General Hospital, Beijing, 100853, P.R. China.