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Current Stem Cell Research & Therapy
ISSN (Print): 1574-888X
ISSN (Online): 2212-3946
VOLUME: 9
ISSUE: 3
DOI: 10.2174/1574888X09666140213202227









Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine

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Author(s): Yuanzhi Xu, Jing Wang, Runyi Mao, Xiaoshan Tang, Renhuan Huang, Raorao Wang and Yunfeng Lin
Pages 244-253 (10)
Abstract:
In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
Keywords:
Application, degenerative disease, differentiation, epigenetic regulation, induced pluripotent stem cells, regenerative medicine.
Affiliation:
Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yanchang Road, Shanghai 200072, P.R. China.