Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Emerging Roles of microRNAs in Neural Stem Cells

Author(s): Sheng Wang, Juan Xu, Rui Ye, Jing Wang, Zhaozhao Chen, Renhuan Huang, Qiang Peng, Yuanzhi Xu, Xiaoxiao Cai.

Abstract:

Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are regulated have been widely explored to improve their therapeutic efficacy in treating neurologic disorders. Recent progress has highlighted the significance of microRNAs (miRNAs) in the regulation of NSC behavior. Thus, to sketch out a comprehensive image of the regulatory mechanisms of miRNAs in NSCs, we here summarize existing evidence of the regulatory roles of diversified miRNAs in the proliferation and neural differentiation of NSCs during embryonic neurodevelopment and adult brain maintenance.

Keywords: Adult neural stem cell, differentiation, embryonic neural stem cell, microRNAs, proliferation, regulation

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2014
Page: [234 - 243]
Pages: 10
DOI: 10.2174/1574888X09666140213201846
Price: $58