Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


The Properties of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its Applications in Tissue Engineering

Author(s): Qixiang Yang, Jing Wang, Shu Zhang, Xiaoshan Tang, Guangwei Shang, Qiang Peng, Raorao Wang and Xiaoxiao Cai

Affiliation: Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301., Middle Yanchang Road, Shanghai 200072, P.R. China.

Keywords: Biocompatibility, biodegradability, mechanical properties, osteoblast, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate), tissue engineering.


Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a member of the polyhydroxyalkanoate (PHA) family. It is the designation of molecules consisting of random co-polymers of 3-hydroxybutyrate and 3- hydroxyhexanoate. PHBHHx plays a significant role in the field of biomedical materials. It has good physical, chemical and mechanical properties, making it potentially useful for a wide range of biomaterials applications. In addition, it has also shown better biocompatibility with different cell types. This paper will introduce the physical, chemical and biological properties of PHBHHx, including biodegradation, hydrophilicity, surface properties and cytocompatibility. The development of PHBHHx in tissue-engineering applications will be discussed. PHBHHx used to repair bone, cartilage, tendons, nerves and vessels will be the focus of discussion.

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Article Details

Page: [215 - 222]
Pages: 8
DOI: 10.2174/1574888X09666140213160853