The Properties of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its Applications in Tissue Engineering
Qixiang Yang, Jing Wang, Shu Zhang, Xiaoshan Tang, Guangwei Shang, Qiang Peng, Raorao Wang and Xiaoxiao Cai
Affiliation: Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301., Middle Yanchang Road, Shanghai 200072, P.R. China.
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a member of the polyhydroxyalkanoate (PHA)
family. It is the designation of molecules consisting of random co-polymers of 3-hydroxybutyrate and 3-
hydroxyhexanoate. PHBHHx plays a significant role in the field of biomedical materials. It has good physical, chemical
and mechanical properties, making it potentially useful for a wide range of biomaterials applications. In addition, it has
also shown better biocompatibility with different cell types. This paper will introduce the physical, chemical and biological
properties of PHBHHx, including biodegradation, hydrophilicity, surface properties and cytocompatibility. The development
of PHBHHx in tissue-engineering applications will be discussed. PHBHHx used to repair bone, cartilage, tendons,
nerves and vessels will be the focus of discussion.
Keywords: Biocompatibility, biodegradability, mechanical properties, osteoblast, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate),
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