Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Potential Replication of Induced Pluripotent Stem Cells for Craniofacial Reconstruction

Author(s): Yao Fu, Shuwen Deng, Jing Wang, Zhaozhao Chen, Shu Zhang, Songtao Wu, Yan Jiang, Ling Ye, Qiang Peng and Yunfeng Lin

Affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14., 3rd Sec, Ren Min Nan Road, Chengdu, 610041. P.R. China.

Keywords: Cell differentiation, craniofacial reconstruction, embryonic stem cells, induced pluripotent stem cells, regenerative medicine, somatic cells.

Abstract:

The craniofacial region contains many specified tissues, including bone, cartilage, muscle, blood vessels, fat, skin and neurons. A defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient’s life. Therefore, functional reconstruction of damaged tissues is highly sought. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound-healing. The recently acquired ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture may provide a powerful tool for in vitro disease modeling and an unlimited source for cell replacement therapy. This review focuses on the generation, biological characterization and discussion of the potential application of iPSCs for craniofacial tissue-engineering applications.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [205 - 214]
Pages: 10
DOI: 10.2174/1574888X09666140213155800