Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

Author(s): Wenjing Yu, Zhen Liu, Shu An, Jinyi Zhao, Lan Xiao, Yongchao Gou, Yunfeng Lin and Jun Wang

Affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, 3rd section, People's South Road, Chengdu, Sichuan 610041, China.


Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone.

Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).

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Article Details

Page: [196 - 204]
Pages: 9
DOI: 10.2174/1574888X09666140213154144