Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

Author(s): Wenjing Yu, Zhen Liu, Shu An, Jinyi Zhao, Lan Xiao, Yongchao Gou, Yunfeng Lin and Jun Wang

Affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, 3rd section, People's South Road, Chengdu, Sichuan 610041, China.

Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).

Abstract:

Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [196 - 204]
Pages: 9
DOI: 10.2174/1574888X09666140213154144