The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration
Wenjing Yu, Zhen Liu, Shu An, Jinyi Zhao, Lan Xiao, Yongchao Gou, Yunfeng Lin and Jun Wang
Affiliation: State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, 3rd section, People's South Road, Chengdu, Sichuan 610041, China.
Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial-
mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts,
and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis.
Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate
into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application
future in tissue engineering and regeneration, especially for the formation of cartilage and bone.
Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed
cells, tissue regeneration, transforming growth factor-β (TGF-β).
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