Electrospun Fibers for Dental and Craniofacial Applications
Guo Li, Tong Zhang, Meng Li, Na Fu, Yao Fu, Kai Ba, Shuwen Deng, Yan Jiang, Jing Hu, Qiang Peng and Yunfeng Lin
Affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14, 3rd Sec, Ren Min Nan Road, Chengdu, 610041. P.R. China.
Electrospinning has been employed extensively in tissue engineering to generate nanofibrous scaffolds from either
natural or synthetic biodegradable polymers. Three-dimensional electrospun scaffolds can create a multi-scale environment
capable of facilitating cell adhesion, proliferation, and differentiation. One such multi-scale scaffold incorporates
nanofibrous features to mimic the extracellular matrix along with a porous network for the regeneration of a variety of tissues.
This review will discuss nanofibrous scaffolds and their tissue-engineering applications in bone, cartilage, periodontium,
tooth, and incorporated drug delivery systems. Combination with other technologies, electrospun scaffolds can contribute
to the field of craniofacial regeneration and advance technology for tissue-engineered replacements in many
physiological systems in near future.
Keywords: Biomaterials, craniofacial, drug delivery, electrospun, stem cell, tissue engineering.
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