Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Electrospun Fibers for Dental and Craniofacial Applications

Author(s): Guo Li, Tong Zhang, Meng Li, Na Fu, Yao Fu, Kai Ba, Shuwen Deng, Yan Jiang, Jing Hu, Qiang Peng and Yunfeng Lin

Affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14, 3rd Sec, Ren Min Nan Road, Chengdu, 610041. P.R. China.

Keywords: Biomaterials, craniofacial, drug delivery, electrospun, stem cell, tissue engineering.

Abstract:

Electrospinning has been employed extensively in tissue engineering to generate nanofibrous scaffolds from either natural or synthetic biodegradable polymers. Three-dimensional electrospun scaffolds can create a multi-scale environment capable of facilitating cell adhesion, proliferation, and differentiation. One such multi-scale scaffold incorporates nanofibrous features to mimic the extracellular matrix along with a porous network for the regeneration of a variety of tissues. This review will discuss nanofibrous scaffolds and their tissue-engineering applications in bone, cartilage, periodontium, tooth, and incorporated drug delivery systems. Combination with other technologies, electrospun scaffolds can contribute to the field of craniofacial regeneration and advance technology for tissue-engineered replacements in many physiological systems in near future.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [187 - 195]
Pages: 9
DOI: 10.2174/1574888X09666140213151717