Psoriasis and Atherosclerosis: Is There a Need For Novel Biomarkers Assessing Cardiovascular Risk?
Murat Sunbul and Mehmet Agirbasli
Affiliation: Yesilbahar Sok. 68/14 Goztepe 34726 Istanbul Turkey.
Epidemiological studies indicate increased mortality rates in cohorts of patients with psoriatic arthritis (PsA). Psoriasis is associated
with an enhanced cardiovascular risk. The excess mortality in psoriasis and PsA is predominantly due to coronary artery disease.
The aim of this review is to overview the biomarkers and/or mediators of increased cardiovascular risk in patients with psoriasis and PsA.
We searched through Medline/PubMed to retrieve sources on cardiovascular disease (CVD), related risk factors and inflammatory markers
in psoriasis and PsA. We analyzed the relationship between psoriasis and novel vascular biomarkers with potential use for preventive
studies. Studies underline the importance of considering psoriatic patients as a high-risk population in terms of CVD. Novel biomarkers
of inflammation, thrombosis, oxidative stress and atherosclerosis can provide risk stratification and strategies for early detection and
treatment of CVD in patients with psoriasis. A better understanding of the association between psoriasis and vascular risk can help the
clinician to manage the increased morbidity and mortality related to CVD.
Keywords: Cardiovascular risk, psoriasis, psoriatic arthritis, inflammation, biomarker, atherosclerosis.
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