Use of Benzodiazepines and Haloperidol Among Orthopedic Patients in Postoperative Delirium. A Systematic Review
Mateusz Szymczak, Joanna Iskra-Trifunovic, Anna Grzywacz, Jerzy Samochowiec and Lukasz Kolodzie
Affiliation: Department of Orthopedics, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Keywords: Benzodiazepines, haloperidol, hip fracture, olanzapine, orthopedic, postoperative delirium.
Postoperative delirium may occur as a serious complication after orthopedic surgery. In addition, risk factors
such as age, mental and organic illnesses may increase the incidence of the aforementioned complication. Delirium has a
negative impact on postoperative mobilization and recovery. Furthermore, it may result in longer hospital treatment. This
study is a systematic literature review of articles that was conducted through a key word search of PubMed. The review
includes: 1) pathogenesis, 2) risk factors in the development of postoperative delirium, and 3) the effective methods and
strategies of treatment, especially in relation to patients hospitalized in orthopedics.
This systematic review will discuss benzodiazepines and haloperidol, which are used to treat delirium in the prevention
and treatment of postoperative delirium. The findings suggest that prevention of postoperative delirium with drugs can be
an effective strategy.
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