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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
Epub Full Text Article
DOI: 10.2174/1381612820666140212205455      Price:  $95









Regulation and Function of Rankl in Arterial Calcification

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Author(s): Belinda A. Di Bartolo and Mary M. Kavurma
Abstract:
Receptor activator of nuclear factor-κB ligand (RANKL) is member of the tumour necrosis factor family important in bone remodelling. Recent evidence suggest that calcification in the vessel wall is equivalent to mechanisms mediating bone formation. This review highlights the role of RANKL in vascular arterial calcification. Here, the relationship between RANKL, osteoprotegerin (OPG) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) are discussed. Furthermore, we focus on the regulatory mechanisms mediating RANKL gene expression and transcription in cells of the vessel wall. A better understanding of RANKL-mediated signalling may help develop more sophisticated cell-based therapies to inhibit calcification of the vessel wall
Keywords:
Receptor activator of nuclear factor-, osteoprotegerin (OPG), tumour necrosis factor-related apoptosisinducing ligand (TRAIL), arterial calcification
Affiliation:
Heart Research Institute, Sydney, NSW 2042, Australia