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Recent Patents on Drug Delivery & Formulation
ISSN (Print): 1872-2113
ISSN (Online): 2212-4039
Epub Full Text Article
DOI: 10.2174/1872211308666140211122012      Price:  $140









Review of Patents and Application of Spray Drying in Pharmaceutical, Food and Flavor Industry

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Author(s): Bhavesh B Patel, Jayvadan K Patel and Subhashis Chakraborty
Abstract:
Spray drying always remains as an energetic field of innovation in pharmaceutical, food and flavor industry since last couple of decades. The current communication embodies an in-depth application of spray drying in pulmonary drug delivery for production of uniform and respirable size particles suitable for nebulizers, dry powder inhalers (DPI) and pressurized metered dose inhalers (pMDI). Review also highlights application of spray drying in the manufacturing of mucoadhesive formulation suitable for nasal cavities to improve the drug absorption and bioavailability. Spray drying is a solvent evaporation based solid dispersion technology and is also widely useful in solubility enhancement of poorly soluble drugs. Recent research works and patents filed by various researchers on spray drying technology for solubility enhancement have also been accentuated. Benefits of spray drying in the production of dry flavorings to achieve a final product with maximum yield and minimum flavor loss are also discussed. The use of spray drying in production of various food products like milk or soymilk powder, tomato pulp, dry fruit juice, encapsulation of vegetable oil or fish oil and dry creamer have been discussed. Current review also highlights application of spray drying in biotechnology field like production of dry influenza or measles vaccine as well as application in ceramic industry. Spray drying based patents, issued by the U.S. Patent and Trademark Office in the area of drug delivery, are also included in this review to emphasize the importance of spray drying in the current research scenario
Keywords:
Food and flavor industry, nasal drug delivery, pulmonary drug delivery, solubility enhancement, solid dispersion, spray drying, US patent
Affiliation:
Technical Service, Pharma Polymer, Research Centre India (RCI), Evonik India Pvt Ltd., Krislon house-First floor, Sakivihar road, Sakinaka, Andheri (E), Mumbai 400 072, Maharashtra, India