Review of Patents and Application of Spray Drying in Pharmaceutical, Food and Flavor Industry
Bhavesh B. Patel, Jayvadan K. Patel and Subhashis Chakraborty
Affiliation: Technical Service, Pharma Polymer, Research Centre India (RCI), Evonik India Pvt Ltd., Krislon house-First floor, Sakivihar road, Sakinaka, Andheri (E), Mumbai 400 072, Maharashtra, India; Also pursuing Ph. D in Pharmaceutics from Hemchandracharya North Gujarat University, Patan 384 265, Gujarat, India.
Keywords: Food and flavor industry, nasal drug delivery, pulmonary drug delivery, solubility enhancement, solid dispersion,
spray drying, US patent.
Spray drying has always remained an energetic field of innovation in pharmaceutical, food and flavor industry
since last couple of decades. The current communication embodies an in-depth application of spray drying in pulmonary
drug delivery for production of uniform and respirable size particles suitable for nebulizers, dry powder inhalers (DPI)
and pressurized metered dose inhalers (pMDI). The review also highlights spray drying application in the manufacturing
of mucoadhesive formulation suitable for nasal cavities to improve the drug absorption and bioavailability. Recent research
works and patents filed by various researchers on spray drying technology for solubility enhancement have also
been accentuated. Benefits of spray drying in production of dry flavorings to meet a product with maximum yield and
least flavor loss are also discussed. The use of spray drying in production of various food products like milk or soymilk
powder, tomato pulp, dry fruit juice etc, and in encapsulation of vegetable oil or fish oil and dry creamer has been discussed.
Current review also highlights the application of spray drying in the biotechnology field like production of dry influenza
or measles vaccine as well as application in ceramic industry. Spray drying based patents issued by the U.S. Patent
and Trademark Office in the area of drug delivery have also been included in the current review to emphasize importance
of spray drying in the recent research scenario.
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