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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
Epub Full Text Article
DOI: 10.2174/1386207317666140211100000      Price:  $95









Label-Free Cell Phenotypic Drug Discovery

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Author(s): Ye Fang
Abstract:
Phenotypic screen holds great potential in the discovery of new small molecule probes and drugs, as it permits interrogating small molecules with native targets and pathways in model organisms and disease relevant cells. In the past years, label-free cell phenotypic profiling has been emerging an alternative for drug discovery. This paper provides the rational for phenotypic screens, discusses the basics of label-free cell phenotypic profiling technologies, and provides some guidelines as to how to use these techniques to facilitate drug discovery
Keywords:
Label-free cell phenotypic screen, phenotypic screen, polypharmacology, target-directed drug discovery
Affiliation:
Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York 14831, USA