Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature
Affiliation: Department of Dyestuff Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai - 400 019, India.
Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using
deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by
Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone
and offered the chromenes in good to excellent yield.
Keywords: 5-exo-Cyclisation, 6-endo Cyclization, AIBN, Pyrimidine, Radical reaction, Sulfur heterocycles, Tributyltin
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