Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature

Author(s): Atul Chaskar

Affiliation: Department of Dyestuff Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai - 400 019, India.

Keywords: 5-exo-Cyclisation, 6-endo Cyclization, AIBN, Pyrimidine, Radical reaction, Sulfur heterocycles, Tributyltin hydride.

Graphical Abstract:


Abstract:

Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone and offered the chromenes in good to excellent yield.

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Article Details

VOLUME: 11
ISSUE: 7
Page: [480 - 486]
Pages: 7
DOI: 10.2174/1570178611666140210213413