Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature

Title:Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature

Volume: 11 Issue: 7

Author(s): Atul Chaskar

Affiliation:

Keywords: 5-exo-Cyclisation, 6-endo Cyclization, AIBN, Pyrimidine, Radical reaction, Sulfur heterocycles, Tributyltin hydride.

Abstract: Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone and offered the chromenes in good to excellent yield.

Cite this article as:

Chaskar Atul, Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature, Letters in Organic Chemistry 2014; 11 (7) . https://dx.doi.org/10.2174/1570178611666140210213413