Surfactant Protein D in Chronic Obstructive Pulmonary Disease (COPD)
Dolores Moreno, Alexis Garcia, Diego Lema and Juan B. De Sanctis
Affiliation: Catedra de Patologia General y Fisiopatologia, Facultad de Medicina, Universidad Central de Venezuela, Caracas 1050-A, Venezuela.
In the recent years, a large number of potential biomarkers for Chronic Obstructive Pulmonary Disease
(COPD) have been described. One of the important biomarkers is Surfactant Protein D (SPD) since serum SPD levels
have been associated with lung function or health status in patients with severe COPD. Several interesting evidences of
the protein and gene polymorphisms have been described. The present review highlights the current literature, recent patents
and, future prospects of this important collection.
Keywords: Biomarkers, COPD, exacerbations, genetic polymorphism, lung surfactant, SP-D.
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