Facile Synthesis of 1,2,4-trisubstituted Imidazoles via Aerobic Copper Catalyzed Ligand-free [3+2] Cycloaddition

Author(s): Wei Li , Weixiang Jiao Wan Tian , Ming Lei .

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 5 , 2014

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A simple and facile approach to highly functionalized imidazole derivatives in moderate to good yields has been developed. This method involves copper catalyzed aerobic [3+2] cycloaddition of amidines with nitroolefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.

Keywords: Copper catalyzed reaction, nitroolefin, amidine, [3+2] cycloaddition, imidazole derivatives.

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Article Details

Year: 2014
Page: [386 - 392]
Pages: 7
DOI: 10.2174/1570178611666140207221202
Price: $58

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