A series of new fluorinated thieno[2,3-d]pyrimidine derivatives containing hydrazone substructure was
synthesized by a five-step procedure, including trifluoroacetylation, cyclization, chlorination, substitution by hydrazine,
and condensation reaction. The structures of these newly synthesized compounds were confirmed by IR, NMR, EI-MS,
elemental analysis and single-crystal X-ray diffraction. The preliminary bioassay result showed that some title compounds
exhibited relatively good fungicidal activity against Fusarium oxysporium f.sp.vasinfectum at the concentration of 50
μgmL-1, especially the inhibition rate of compound 6b reached above 90%.
Keywords: Crystal structure, fungicidal activity, hydrazones, thieno[2, 3-d]pyrimidines, trifluoromethyl group.
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