Microtubule-targeting Anticancer Agents from Marine Natural Substance

Author(s): Zhiguo Liu, Pengfei Xu, Tao Wu, Wenbin Zeng.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 14 , Issue 3 , 2014

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Abstract:

Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.

Keywords: Anticancer, marine, microtubule, natural products.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2014
Page: [409 - 417]
Pages: 9
DOI: 10.2174/187152061403140207163402
Price: $58

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