Microtubule-targeting Anticancer Agents from Marine Natural Substance
Zhiguo Liu, Pengfei Xu, Tao Wu and Wenbin Zeng
Affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance.
Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting
compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products
(MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway
to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive
marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.
Keywords: Anticancer, marine, microtubule, natural products.
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