Lung Function In Health And Disease: Basic Concepts of Respiratory Physiology and Pathophysiology

Indexed in: Book Citation Index, Science Edition, EBSCO.

This reference presents basic concepts relevant to respiratory function in normal and diseased states.The volume stresses a quantitative approach to physical parameters used as indicators of normal ...
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Acid-Base Balance

Pp. 122-149 (28)

Nasr H. Anaizi


This chapter deals with acid-base homeostasis with special emphasis on the role of the respiratory system. After explaining why maintaining a relatively constant proton activity is critical to optimal cellular function we define acid-base balance and describe the basic mechanisms responsible for acid-base homeostasis. After describing the unique role of the HCO3-/CO2 buffer pair in acid-base regulation the four primary acid-base disturbances are defined. Finally an extensive outline is presented of the various approaches for the evaluation of acid-base disorders followed by examples and a few clinical cases.


Acid-Base Disorders, Acid-Base Homeostasis, Acidemia, Acidosis, Alkalemia, Alkalosis, Anion Gap, Base Excess, Buffering Capacity, Davenport Diagram, Henderson-Hasselbalch, Hydrogen Ions, Imidazole Group, Metabolic Acidosis, Metabolic Alkalosis, pH, pKa, Respiratory Acidosis, Respiratory Alkalosis, Standard Bicarbonate.


Department of Pharmacology and Physiology University of Rochester, School of Medicine and Dentistry 601 Elmwood Ave. Rochester, NY 14642-8711 USA