Lung Function In Health And Disease: Basic Concepts of Respiratory Physiology and Pathophysiology

Indexed in: Book Citation Index, Science Edition, EBSCO.

This reference presents basic concepts relevant to respiratory function in normal and diseased states.The volume stresses a quantitative approach to physical parameters used as indicators of normal ...
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Acid-Base Balance

Pp. 122-149 (28)

Nasr H. Anaizi

Abstract

This chapter deals with acid-base homeostasis with special emphasis on the role of the respiratory system. After explaining why maintaining a relatively constant proton activity is critical to optimal cellular function we define acid-base balance and describe the basic mechanisms responsible for acid-base homeostasis. After describing the unique role of the HCO3-/CO2 buffer pair in acid-base regulation the four primary acid-base disturbances are defined. Finally an extensive outline is presented of the various approaches for the evaluation of acid-base disorders followed by examples and a few clinical cases.

Keywords:

Acid-Base Disorders, Acid-Base Homeostasis, Acidemia, Acidosis, Alkalemia, Alkalosis, Anion Gap, Base Excess, Buffering Capacity, Davenport Diagram, Henderson-Hasselbalch, Hydrogen Ions, Imidazole Group, Metabolic Acidosis, Metabolic Alkalosis, pH, pKa, Respiratory Acidosis, Respiratory Alkalosis, Standard Bicarbonate.

Affiliation:

Department of Pharmacology and Physiology University of Rochester, School of Medicine and Dentistry 601 Elmwood Ave. Rochester, NY 14642-8711 USA