Lung Function In Health And Disease: Basic Concepts of Respiratory Physiology and Pathophysiology

Indexed in: Book Citation Index, Science Edition, EBSCO.

This reference presents basic concepts relevant to respiratory function in normal and diseased states.The volume stresses a quantitative approach to physical parameters used as indicators of normal ...
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Respiratory Mechanics

Pp. 47-79 (33)

Camillo Peracchia


This chapter focuses on the elastic properties of the respiratory system and on the mechanisms by which gases are flown in and out of the lungs during the breathing cycle. It begins by defining the lung volumes (capacities) and describing methods used for measuring them. Then, it describes the mechanisms of inspiration and expiration and the relationship between respiratory muscles and elastic characteristics of the respiratory system. The properties of respiratory mechanics are then divided into two sections: static and dynamic. Static mechanics deals with elastic characteristics of lungs, chest wall and the combined lungs + chest wall system, and with methods used for quantifying them. The relevance of surface tension and surfactant in modulating lung compliance and in maintaining the alveoli dry is discussed in detail. Dynamic mechanics discusses how gases flow through airways during the breathing cycle. Alveolar and intra-pleural pressures changes during normal breathing and while breathing through narrowed airways are described, as well as mechanism causing airway collapse in patients with loss of lung elasticity (emphysema), or suffering from extra-thoracic airway obstruction. The last two sections deal with the work of breathing and the most common pulmonary function tests.


Airway Collapse, Airway Resistance, Bernoulli Principle, Breathing Cycle, Chest-Wall Compliance, Diaphragm, Elastance, Expiratory Muscles, Inspiratory Muscles, Intercostal Muscles, Laminar Flow, Lung Compliance, Lung Volumes, Plethysmography, Pulmonary Function-Tests, Respiratory Work, Spirometry, Surface Tension, Surfactant, Trans-Pulmonary Pressure, Turbulent Flow.


Department of Pharmacology and Physiology University of Rochester, School of Medicine and Dentistry 601 Elmwood Ave. Rochester, NY 14642-8711 USA