Glioblastoma Stem-Like Cells – Isolation, Biology and Mechanisms of Chemotherapy Resistance
Iwona Anna Ciechomska, Marta Kocyk and Bozena Kaminska
Affiliation: Nencki Institute of Experimental Biology, 3 Pasteur Str., 02-093 Warsaw, Poland.
Keywords: Glioblastoma, glioma-initiating cells (GIC), glioma stem cells (GSC), functional characteristics, isolation, markers,
Malignant gliomas are common primary tumors of the central nervous system, characterized by aggressive cell
proliferation, diffuse infiltration and resistance to conventional therapy. Glioblastoma (former Glioblastoma multiforme,
GBM), grade IV astrocytoma, is the most aggressive tumor, with a median survival of around 14 months. New therapies
against this devastating and invariably fatal disease are needed. Stem-like cell populations have been identified in a
number of malignancies including glioblastoma. These rare stem cells (called also glioma-initiating cells) are believed to
be responsible not only for tumor initiation and progression but also resistance to therapeutic agents and tumor recurrence.
Recently, the population of cells within glioblastoma with stem-like properties has gained increasing attention as a target
to refine treatment strategies. This chapter aims to summarize the recent data regarding isolation, biology and mechanisms
of resistance of glioblastoma stem-like cells to therapy.
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