First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection

Author(s): Leonor Y. Vargas Mendez, Vladimir V. Kouznetsov.

Journal Name: Current Organic Synthesis

Volume 10 , Issue 6 , 2013

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Abstract:

An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction, and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity.

Keywords: AChE inhibitory activity, alkaloids, α-Aminonitriles, antioxidant capacity, girgensohnine, Strecker reaction.

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2013
Page: [969 - 973]
Pages: 5
DOI: 10.2174/157017941006140206105449
Price: $58

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