Peptide-Based Nanostructures for Cancer Diagnosis and Therapy

Author(s): Linna An, M. Rehan H. Shah Gilani, Gaolin Liang.

Journal Name: Current Medicinal Chemistry

Volume 21 , Issue 21 , 2014

Abstract:

Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properties of pep-NPs such as nanostructure formation and ability of drug delivery. Meanwhile, the peptide sequences based on natural/unnatural amino acids could be utilized for designing nanostructures susceptive/resistant to specific enzymes. Herein, we firstly summarize the basic peptide structures to provide a whole image of pep-NPs. Subsequently, the diagnostic strategies based on different imaging modalities and recent therapeutic applications of pep-NPs for cancer are reviewed.

Keywords: Cancer, diagnosis, drug delivery, imaging, peptide-based nanoparticles, therapy.

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Article Details

VOLUME: 21
ISSUE: 21
Year: 2014
Page: [2453 - 2466]
Pages: 14
DOI: 10.2174/0929867321666140205140600
Price: $58

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