Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Peptides-Staple Method Development and Its Application in Cancer Therapy

Author(s): Q.Z. Zhang, Y. Tian, Y.Z. Lao, Z.-G. Li.

Abstract:

α-Helixes are important structural motifs of protein three dimension structures and are largely involved in protein- protein interactions. This review covers the recent advances of the peptide stabilizing methodologies and introduces their applications in cancer research.

Keywords: Cancer therapy, protein-protein interaction, stapled peptide, α-helix.

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Article Details

VOLUME: 21
ISSUE: 21
Year: 2014
Page: [2438 - 2452]
Pages: 15
DOI: 10.2174/0929867321666140205130835
Price: $58