Decarboxylative Fluorination Strategies for Accessing Medicinally- Relevant Products
Yupu Qiao, Lingui Zhu, Brett R. Ambler and Ryan A. Altman
Affiliation: Department of Medicinal Chemistry, the University of Kansas, 1251 Wescoe Hall Dr., 4046A Malott Hall, Lawrence, KS 66045, USA.
Fluorinated organic compounds have a long history in medicinal chemistry, and synthetic methods to access
target fluorinated compounds are undergoing a revolution. One powerful strategy for the installation of fluorinecontaining
functional groups includes decarboxylative reactions. Benefits of decarboxylative approaches potentially include:
1) readily available substrates or reagents 2) mild reaction conditions; 3) simplified purification. This focus review
highlights the applications of decarboxylation strategies for fluorination reactions to access compounds with biomedical
potential. The manuscript highlights on two general strategies, fluorination by decarboxylative reagents and by decarboxylation
of substrates. Where relevant, examples of medicinally useful compounds that can be accessed using these
strategies are highlighted.
Keywords: Decarboxylation, fluorination, difluoromethylation, trifluoromethylation, copper.
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