In recent years, several new fluorinated functional groups have been employed in medicinal chemistry. This review
will highlight some recent developments in this area. We draw attention to useful synthetic advances for the installation
of fluorine-containing groups. In addition, we examine the application of some fluorinated functional groups that
have recently been gaining popularity in drug discovery. We use matched-pair analysis to assemble aggregate data on the
impact on potency of one of these groups, pentafluorosulfanyl, as compared to trifluoromethyl. We further used matchedpair
analysis to identify some interesting effects on in vitro ADME properties of replacing H by F on certain moieties.
Keywords: Difluoroalkyl, fluorine, matched-pairs analysis, metabolic stability, pentafluorosulfanyl, trifluoromethylcyclopropyl.
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