Current Organic Chemistry


Recent Developments for the Synthesis of Heterocycles Catalyzed by N-Heterocyclic Carbene

Author(s): Qiuping Ding, Xiaona Fan and Jie Wu

Affiliation: School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, China and Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

Graphical Abstract:


N-Heterocyclic carbenes (NHCs) as versatile nucleophilic organocatalysts have been extensively studied and also widely applied in organic reactions. The types of organic reactions catalyzed by N-heterocyclic carbenes are broad including benzoin condensation, Stetter reaction, a3-to-d3 umpolung, ring-opening reaction, transesterification, and ring expansion polymerization. This review reports recent developments in the synthesis of heterocycles (such as lactams, lactones, chromones, and benzofuranones) catalyzed by N-heterocyclic carbenes.

Keywords: Benzofuranone, chromone, heterocycles, lactam, lactone, N-heterocyclic carbene, organocatalyst.

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Article Details

Page: [700 - 718]
Pages: 19
DOI: 10.2174/1385272819666140201003238
Price: $58