Reactions of 1,2- & 1,4-dihydropyridines
Sunil K. Singh and Vivek K. Sharma
Affiliation: Department of Chemistry, Kirori Mal College, University of Delhi, Delhi-110 007, India.
Keywords: 1, 2- 1, 4-Dihydropyridines, aromatization, cycloaddition, diamination, oxidation, oxyselenation, photodimerisation, rearrangement.
This review provides a comprehensive compilation of available literature concerning the reactions of 1,2- & 1,4-
dihydropyridines, which have opened new frontiers in the area of synthetic and medicinal chemistry. These reactions mainly include cycloaddition,
1,3-Dipolar cycloaddition, alkoxy halogenation, diamination, hydroxyamination, oxidation, hydroxylation, photooxygenation
reaction, nucleophilic addition, cyclization, electrophilic substitution, multicomponent reactions (MCRs) and rearrangement reactions.
1,4-Dihydropyridine has also been used in hydrogen transfer reactions as a synthetic NADH model for the reduction of several important
molecules in excellent yields.
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