Current Organic Chemistry

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Reactions of 1,2- & 1,4-dihydropyridines

Author(s): Sunil K. Singh and Vivek K. Sharma

Affiliation: Department of Chemistry, Kirori Mal College, University of Delhi, Delhi-110 007, India.

Keywords: 1, 2- 1, 4-Dihydropyridines, aromatization, cycloaddition, diamination, oxidation, oxyselenation, photodimerisation, rearrangement.

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Abstract:

This review provides a comprehensive compilation of available literature concerning the reactions of 1,2- & 1,4- dihydropyridines, which have opened new frontiers in the area of synthetic and medicinal chemistry. These reactions mainly include cycloaddition, 1,3-Dipolar cycloaddition, alkoxy halogenation, diamination, hydroxyamination, oxidation, hydroxylation, photooxygenation reaction, nucleophilic addition, cyclization, electrophilic substitution, multicomponent reactions (MCRs) and rearrangement reactions. 1,4-Dihydropyridine has also been used in hydrogen transfer reactions as a synthetic NADH model for the reduction of several important molecules in excellent yields.

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Article Details

VOLUME: 18
ISSUE: 9
Page: [1159 - 1207]
Pages: 49
DOI: 10.2174/1385272819666140201003050