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Current Organic Chemistry
ISSN (Print): 1385-2728
ISSN (Online): 1875-5348
Epub Abstract Ahead of Print
DOI: 10.2174/1385272819666140201002503      Price:  $95

Biologically Active Synthetic Anionophores

Author(s): Claude-rosny Elie, Marc Vidal, Mathieu Charbonneau, Audrey Hebert and Andreea R. Schmitzer
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The physiological importance of proteins that can regulate ion balance and transmembrane transport is highlighted by different diseases where ion channel dysfunction is observed. During the past two decades, considerable effort has been devoted to develop synthetic ionophores that can insert or cross cell membranes and restore the dysfunction of highly complex protein channels responsible to regulate ion concentration.

Notwithstanding the remarkable structural advances made, only a few classes of synthetic ionophores were studied in complex pro- and eukaryote cells in order to obtain information about their biological activity and potential application in ion channel replacement therapy, anti-cancer therapy or antimicrobial treatements. However, a few synthetic ionophores showed promising biological activities in cellular assays. This review aims to show the utility of synthetic ionophores for different biological applications, from restoring ion concentration, inducing cell death in different cancer cells to protection against a variety of pathogenic microbes. Because the activities of these ionophores depend primarily on their overall physicochemical properties and structure, we discuss here specific functional units and scaffolds that are important for obtaining selective, non-toxic transporters for specific biological applications.

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