The Construction Strategies of Mono- and Oligosaccharide Microarrays
Xinya Mei and Gangliang Huang
Pages 615-619 (5)
Carbohydrate microarrays are powerful tools to investigate the recognition events because of carbohydrate-protein interactions
in high-throughput fashion. Some methods have been utilized to immobilize the nonderivatised or derivatised carbohydrates on support
surfaces in the microarray mode. Because polysaccharides have the hydrophobic interactions, polysaccharide arrays are very easy to
construct by non-covalently immobilizing them onto all kinds of microarray surfaces. However, mono- and oligosaccharides have the
hydrophilic interactions. So, they must be derivatised and then covalently or non-covalently immobilized onto microarray surfaces to
construct mono- and oligosaccharide microarrays. Based on the reason, construction strategies of mono- and oligosaccharide microarrays
were analyzed and summed up in recent years herein.
Applications, carbohydrate-protein interactions, construction strategies, mono- and oligosaccharide microarrays.
Key Lab of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.