Advances in Nanomaterials for Diagnosis and Therapy of Leukemia
Swati S. Vyas and Vandana B. Patravale
Affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400019, India.
Numerous efforts in oncological scientific research have revealed many causative facets of leukemia,
explaining mechanistic aspects of disease progression at the molecular scale. Reports record over 40,000 new cases of
patients afflicted with myeloid and lymphocytic leukemia annually worldwide. Early diagnosis and quick therapy are
advantageous in effective treatment. Conventional methods mainly rely on blood cell counts and bone marrow biopsies
for detection but these are inefficient in accurately diagnosing leukemia. Contemporary research has employed core
nanotechnology in designing more efficient diagnostic and theranostic systems for leukemia. In such systems, biological
markers and genetic materials such as siRNA and peptides tagged with nanoparticles (dendrimers, aptamers, and metal
nanoparticles) form the fundamental elements that work at the molecular level and confer a high degree of specificity for
recognition and capture, and in a therapeutic context, cytotoxicity for eradication of cancerous cells. We review current
research and patented technologies that focus on nanomaterials as promising tools in detection and treatment of chronic
and acute leukemia.
Keywords: Diagnosis, leukemia, nanomedicine, theranosis, treatment.
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