The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase
(AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a
microwave synthesizer. Most of the compounds exhibited moderate to good AChE inhibitory activity, compound 5i
showed potent inhibitory activity with IC50 1.12±0.01 µM and this may provide a new lead for developing potential inhibitors
for Alzheimer's disease.
Keywords: Alzheimer's disease, AChE inhibitor, 1, 3-Dipolar cycloaddition, azomethine ylide, diazapentacycles and microwave
Rights & PermissionsPrintExport