Vasospastic Angina and Ca Channel Blockers
Affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan.
Keywords: Ca channel blocker, cardiovascular event, vasospastic angina.
Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular
fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina
(VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what
kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel
blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that
among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than
amlodipine, nifedipine or diltiazem.
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