Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li

Affiliation: Shaanxi university of Chinese medicine, shijidadao, xianyang, 712046, China.

Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

Graphical Abstract:


Abstract:

A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

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Article Details

VOLUME: 11
ISSUE: 6
Page: [736 - 741]
Pages: 6
DOI: 10.2174/1570180811666140130232233