Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song, Na Li.

Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 6 , 2014

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Abstract:

A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2014
Page: [736 - 741]
Pages: 6
DOI: 10.2174/1570180811666140130232233
Price: $58

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