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Recent Patents on Drug Delivery & Formulation
ISSN (Print): 1872-2113
ISSN (Online): 2212-4039
Epub Full Text Article
DOI: 10.2174/1872211308666140130093301      Price:  $140









Drug Delivery to the Back of the Eye Following Topical Administration: An Update on Research and Patenting Activity

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Author(s): Sai HS Boddu, Himanshu Gupta and Soohi Patel
Abstract:
Drug delivery to the back of the eye following topical administration remains an unmet need for the scientific community. Treatment of posterior segment diseases requires localized and long-term drug delivery to the retina, choroid, and Bruch’s membrane. Until the last decade, there was limited evidence from large clinical trials that demonstrated the usefulness of pharmacotherapy compared to laser therapy or other vitreoretinal surgical techniques for the treatment of retinal diseases. This paradigm has shifted in recent years, with strong evidence demonstrating superior efficacy of ophthalmic drugs compared to previous gold standards. However, ophthalmologists are left with no options other than administering the therapeutics via implants and intravitreal injections, which are highly invasive and associated with patient non-compliance. A non-invasive topical therapy would enhance patient compliance and minimize the side-effects associated with intraocular implants and intravitreal injections. In an attempt to enhance patient compliance, the focus of research has shifted to the development of novel small molecule-based eye drop formulations. This review article summarizes the resurgence in the treatment of posterior segment eye diseases through topical drug administration
Keywords:
Drug delivery, eye drops, posterior segment, retinal diseases
Affiliation:
Department of Pharmacy Practice The University of Toledo HSC College of Pharmacy and Pharmaceutical Sciences 3000 Arlington Ave. (MS1013) Toledo, OH 43614