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Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)
ISSN (Print): 1871-5249
ISSN (Online): 1875-6166
Epub Full Text Article
DOI: 10.2174/1871524914666140129122632      Price:  $95









Pyrazoline: A Promising Scaffold for the Inhibition of Monoamine Oxidase

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Author(s): Bijo Mathew, Jerad Suresh, Sockalingam Anbazhagan and Githa Elizabeth Mathew
Abstract:
In the five membered nitrogen containing heterocyclic family, pyrazoline could be recognized as the promising scaffold for the inhibition of Monoamine oxidase. Substitution at 1, 3 and 5-position of the pyrazoline nucleus displayed a significant activity towards MAO in the past 15 years. Our study identified the detailed structure activity relationship, the structural requirement for enzyme interaction and the effect of chirality on the pyrazoline nucleus towards MAO-A and MAO-B. We proposed that the selectivity of pyrazoline nucleus towards MAO isoenzyme depends up on the bulkiness of the ring in the 1st and 3rd position of the scaffold. The current review revealed that the derivatives of pyrazolines has proven a versatile pharmacophore for the inhibition of MAO on the basis of existing literatures between (1998-2013)
Keywords:
Anti-depressant, MAO-A, MAO-B, Chirality, Molecular docking
Affiliation:
Division of Drug Design and Medicinal Chemistry Research Lab,Department of Pharmaceutical Chemistry, Grace College of Pharmacy,Palakkad,Kerala,India