Metastasis and thrombosis are serious threats to cancer patients and generally associated with poor prognosis. The elusive
mechanisms underlying the pathogenesis of metastasis and thrombosis have been subjects of extensive investigations. The presence of
circulating tumor cells (CTCs) is closely related to tumor metastasis, and these cells play an important role in thrombosis in cancer patients.
In this review, we describe the latest findings on the role of CTCs in tumor metastasis and cancer-related thrombosis and the regulatory
role of microRNAs in CTCs and thrombosis. Additionally, we discuss anticoagulant-based strategies for the prevention of thrombosis
and reduction of cancer metastasis and the potential to translate current knowledge on these strategies to the treatment of cancer.
Keywords: Circulating tumor cells, metastasis, thrombosis, microRNA, anticoagulation.
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