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Current Molecular Medicine
ISSN (Print): 1566-5240
ISSN (Online): 1875-5666
VOLUME: 14
ISSUE: 2
DOI: 10.2174/1566524014666140128112827      Price:  $58









Caveolin-1 in Cell Migration and Metastasis

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Author(s): S. Nunez-Wehinger, R.J. Ortiz, N. Diaz, J. Diaz, L. Lobos-Gonzalez and A.F.G. Quest
Pages 255-274 (20)
Abstract:
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.
Keywords:
Cancer progression, Caveolin-1 (CAV1), invasion, metastasis, migration, phosphorylation, tyrosine-14.
Affiliation:
Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile.