Caveolin-1 in Cell Migration and Metastasis
S. Nunez-Wehinger, R.J. Ortiz, N. Diaz, J. Diaz, L. Lobos-Gonzalez and A.F.G. Quest
Pages 255-274 (20)
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early
stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages,
caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms
associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role
of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and
metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as
well as mechanisms by which this may be achieved.
Cancer progression, Caveolin-1 (CAV1), invasion, metastasis, migration, phosphorylation, tyrosine-14.
Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile.