Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

Back

α-ZrP: A Highly Efficient Catalyst for Solvent-free Synthesis of Pyrimido[ 5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-Arylacridinedione Derivatives

Author(s): Shahrzad Abdolmohammadi

Affiliation: Department of Chemistry, Faculty of Science, East Tehran Branch, Islamic Azad University, PO Box 33955-163, Tehran, Iran.

Keywords: 4-Arylacridinediones, pyrimido[5', 4':5, 6]pyrido[2, 3-d]pyrimidinetetraones, reusability of catalyst, solvent-free conditions, Zr(HPO4)2.H2O (α-ZrP).

Graphical Abstract:


Abstract:

A solvent-free approach for the synthesis of a series of pyrimido[5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-arylacridinedione derivatives is described herein. These compounds having biological importance were prepared via a condensation reaction of aryl aldehydes, ammonium acetate and active methylene compounds including 1,3- dimethylbarbituric acid or dimedone under solvent-free conditions, using Zr(HPO4)2.H2O (α-ZrP) as an efficient catalyst. The reusability of catalyst and easier isolation of the products along with high yields of products are the advantages of this eco-friendly and versatile protocol.

Reprint ePrint Rights & PermissionsPrintExport

Article Details

VOLUME: 11
ISSUE: 6
Page: [465 - 469]
Pages: 5
DOI: 10.2174/1570178611666140124002242