A solvent-free approach for the synthesis of a series of pyrimido[5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and
4-arylacridinedione derivatives is described herein. These compounds having biological importance were prepared via a
condensation reaction of aryl aldehydes, ammonium acetate and active methylene compounds including 1,3-
dimethylbarbituric acid or dimedone under solvent-free conditions, using Zr(HPO4)2.H2O (α-ZrP) as an efficient catalyst.
The reusability of catalyst and easier isolation of the products along with high yields of products are the advantages of this
eco-friendly and versatile protocol.
Keywords: 4-Arylacridinediones, pyrimido[5', 4':5, 6]pyrido[2, 3-d]pyrimidinetetraones, reusability of catalyst, solvent-free
conditions, Zr(HPO4)2.H2O (α-ZrP).
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