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Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
VOLUME: 11
ISSUE: 6
DOI: 10.2174/1570178611666140124002242      Price:  $58









α-ZrP: A Highly Efficient Catalyst for Solvent-free Synthesis of Pyrimido[ 5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-Arylacridinedione Derivatives

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Author(s): Shahrzad Abdolmohammadi
Pages 465-469 (5)
Abstract:
A solvent-free approach for the synthesis of a series of pyrimido[5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-arylacridinedione derivatives is described herein. These compounds having biological importance were prepared via a condensation reaction of aryl aldehydes, ammonium acetate and active methylene compounds including 1,3- dimethylbarbituric acid or dimedone under solvent-free conditions, using Zr(HPO4)2.H2O (α-ZrP) as an efficient catalyst. The reusability of catalyst and easier isolation of the products along with high yields of products are the advantages of this eco-friendly and versatile protocol.
Graphical Abstract:
Keywords:
4-Arylacridinediones, pyrimido[5', 4':5, 6]pyrido[2, 3-d]pyrimidinetetraones, reusability of catalyst, solvent-free conditions, Zr(HPO4)2.H2O (α-ZrP).
Affiliation:
Department of Chemistry, Faculty of Science, East Tehran Branch, Islamic Azad University, PO Box 33955-163, Tehran, Iran.