α-ZrP: A Highly Efficient Catalyst for Solvent-free Synthesis of Pyrimido[ 5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-Arylacridinedione Derivatives

Title:α-ZrP: A Highly Efficient Catalyst for Solvent-free Synthesis of Pyrimido[ 5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-Arylacridinedione Derivatives

Volume: 11 Issue: 6

Author(s): Shahrzad Abdolmohammadi

Affiliation:

Keywords: 4-Arylacridinediones, pyrimido[5', 4':5, 6]pyrido[2, 3-d]pyrimidinetetraones, reusability of catalyst, solvent-free conditions, Zr(HPO₄)₂.H₂O (α-ZrP).

Abstract: A solvent-free approach for the synthesis of a series of pyrimido[5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-arylacridinedione derivatives is described herein. These compounds having biological importance were prepared via a condensation reaction of aryl aldehydes, ammonium acetate and active methylene compounds including 1,3- dimethylbarbituric acid or dimedone under solvent-free conditions, using Zr(HPO₄)₂.H₂O (α-ZrP) as an efficient catalyst. The reusability of catalyst and easier isolation of the products along with high yields of products are the advantages of this eco-friendly and versatile protocol.

Cite this article as:

Abdolmohammadi Shahrzad, α-ZrP: A Highly Efficient Catalyst for Solvent-free Synthesis of Pyrimido[ 5',4':5,6]pyrido[2,3-d]pyrimidinetetraone and 4-Arylacridinedione Derivatives, Letters in Organic Chemistry 2014; 11 (6) . https://dx.doi.org/10.2174/1570178611666140124002242