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Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
VOLUME: 11
ISSUE: 5
DOI: 10.2174/1570178611666140124001937      Price:  $58









An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D

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Author(s): Indraganti Sreenivasa Murthy, Reddymasu Sreenivasulu, Gurrala Alluraiah and Rudraraju Ramesh Raju
Pages 327-332 (6)
Abstract:
An efficient stereoselective total synthesis of (+)-Cephalosporolide D from commercially available and inexpensive starting material, (±)-propylene epoxide, is described. The key steps involved in this synthesis are α- aminoxylation catalyzed by L-proline, followed by in situ reduction using NaBH4 and Yamaguchi macrolactonization.
Keywords:
(+)-Cephalosporolide D, L - Proline catalyzed reaction, (±)-Propylene epoxide, stereoselective synthesis, total synthesis and Yamaguchi macrolactonization.
Affiliation:
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510, Andhra Pradesh, India.