An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D
Indraganti Sreenivasa Murthy, Reddymasu Sreenivasulu, Gurrala Alluraiah and Rudraraju Ramesh Raju
Affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar - 522 510, Andhra Pradesh, India.
Keywords: (+)-Cephalosporolide D, L - Proline catalyzed reaction, (±)-Propylene epoxide, stereoselective synthesis, total
synthesis and Yamaguchi macrolactonization.
An efficient stereoselective total synthesis of (+)-Cephalosporolide D from commercially available and
inexpensive starting material, (±)-propylene epoxide, is described. The key steps involved in this synthesis are α-
aminoxylation catalyzed by L-proline, followed by in situ reduction using NaBH4 and Yamaguchi macrolactonization.
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